Formulation and Characterization of Thermostable Nanostructured Lipid Nanocarrier for mRNA vaccine Delivery

Abstract

mRNA-based vaccines become alternatives for the quick and cost-effective production to address a growing number of infectious disease including cancer immune therapies. The fragile molecule mRNA, should be protected against extracellular degradation for increasing the effectiveness of the vaccine. Lipid Nanoparticles (LNPs) are most clinically advanced non-viral vectors that used in targeted intracellular delivery of mRNA.