SYNTHESIS AND STUDY OF MALONONITRILE BASED PYRIMIDINES AND ITS ANTIMICROBIAL ACTIVITY
Keywords:
Chalcones, Pyrimidine, Malononitrile, Spectroscopy, Antimicrobial ActivityAbstract
Pyrimidine serves as a crucial intermediate compound in the synthesis of heterocyclic compounds, which are significant due to their medicinal applications. The exploration of heterocyclic systems is of considerable interest for both their medicinal properties and synthetic potential. These compounds are vital in the development of new pharmacologically active motifs. Chalcones play a key role in the synthesis of pyrimidine derivatives.
In this study, chalcones were synthesized through a one-pot condensation process involving 4-chloroaniline and 1-(5-hydroxynaphthalen-1-yl) ethenone, followed by further condensation with various aromatic aldehydes. The resulting chalcones (designated A1-A15) were then refluxed with malononitrile to produce a range of pyridine derivatives (designated B1-B15). The synthesized compounds were characterized using 1HNMR, 13CNMR, IR, and MASS spectrometry, and were evaluated for antimicrobial activity against both Gram-positive and Gram-negative bacteria.
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