Variant Analytics of the Sars-Cov-2 Genome in South Karnataka Revealed Significance for Drug Resistance

Variant Analytics of the Sars-Cov-2 Genome in South Karnataka Revealed Significance for Drug Resistance

Authors

  • DR. HARISHCHANDER ANANDARAM

Abstract

The SARS-CoV-2 virus is the vital cause of the pandemic. Combating COVID-19 requires a vaccine design to identify the basic variant patterns, i.e., point mutations and Single Nucleotide Polymorphism (SNPs). Identifying possible variants in the genome of SARS-CoV-2 from a global perspective is the basis for creating a database of Mut.-SNP.-SARS-CoV-2.This study involves selecting the data of the SARS-CoV-2 genome in south Karnataka. The variant analysis resulted in 19 novel variants contributing to the mechanism of drug resistance.

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References

Cui J, Li F, Shi ZL. (2019). Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol, 17: pp. 181–192.

Dong L, Tian J, He S, Zhu C, Wnag J, Liu C et al. (2020). Possible Vertical Transmission of SARS-CoV-2 from an Infected Mother to Her Newborn. JAMA, 323:1846-1848.

Dharma K, Khan S, Tiwari R, Sircar S, Bhat S, Malik YS et al. Coronavirus Disease 2019-COVID-19. Clin Microbiol Rev, 2020;33(4):e00028-20.

Furukawa NW, Brooks JT, Sobel J. (2020). Evidence Supporting Transmission (EST) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) while Presymptomatic or Asymptomatic. Emerg Infect Dis, 26:e201595.

Li Yen-Der, Chi Wei-Yu, Su Jun-Han, Ferrall Louise, Hung Chien-Fu, Wu T-C. (2020). Coronavirus vaccine development: From SARS and MERS to COVID-19. J Biomed Sci, 27:104.

Petrakis D, Margină D, Tsarouhas K, Teckos F, Stan M, Nikitovic D et al. Obesity is a risk factor for increased COVID-19 prevalence, severity and lethality (Review). Mol Med Rep, 2020; 22(1):9-19.

Vijaykrishna D, Smith GJ, Zhang JX, Peiris JS, Chen H, Guan Y. (2007). Evolutionary insights into the ecology of coronaviruses. Journal of Virology, 81: pp. 4012–4020.

Volz E, Mishra S, Chand M, Barrett JC, Johnson R, Geidelberg L et al. (2021). "Assessing transmissibility of SARS-CoV-2 lineage B.1.1.7 in England". Nature, 593: 266-269.

Weiss SR, Navas-Martin S. (2005). Coronavirus pathogenesis (Cp) and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev, 69:635-664.

Additional Files

Published

03-03-2024

How to Cite

DR. HARISHCHANDER ANANDARAM. (2024). Variant Analytics of the Sars-Cov-2 Genome in South Karnataka Revealed Significance for Drug Resistance. Vidhyayana - An International Multidisciplinary Peer-Reviewed E-Journal - ISSN 2454-8596, 9(si2). Retrieved from http://vidhyayanaejournal.org/journal/article/view/1685
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