Optimization of 1,8-Naphthyridine Derivatives Using Ultrasonic Method: Synthesis, Characterization, and Enhanced Properties Study
Keywords:
Morpholine, Ultrasound irradiation, One pot multi-component reaction, Optimization, aqueous conditionAbstract
The increasing concern for environmental sustainability and the need for efficient and green chemical synthesis have driven the development of alternative methods for producing new compound. Compared to more conventional techniques, ultrasonic irradiation offers improved preparation yields, a quicker reaction time and more comfortable conditions. The use of ultrasound sonication is a green and efficient synthetic method that utilizes sound waves to initiate chemical reactions. We optimized various reaction parameters, such as solvent, temperature, catalyst amount, and reaction time, to identify the best reaction conditions for the synthesis of the derivatives. Using morpholine as a catalyst in an aqueous condition and the ultrasonic irradiation method, ethyl 2-oxo-4-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylate and its derivatives were synthesized by taking advantages of this. Synthesized compounds were confirmed through IR, 1H NMR, 13C NMR and mass spectra. This method provides us modern green platform to synthesize and optimize ethyl 2-oxo-4-phenyl-1,2,3,4-tetrahydro-1,8-naphthyridine-3-carboxylate derivatives.
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References
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